Preimplantation genetic testing: a review of current modalities

نویسندگان

چکیده

In this review, we evaluate the different modalities of embryo genetic testing including preimplantation for aneuploidy (PGT-A), monogenic/single-gene abnormalities (PGT-M), and chromosomal structural rearrangements (PGT-SR), with a clinical focus on indications, strengths, limitations, parameters each technique. Articles were obtained from PubMed American College Obstetricians Gynecologists Society Reproductive Medicine committee opinions. While some studies have suggested that PGT-A increases live births in women advanced maternal age, recent large randomized controlled trial has shown no benefit to compared morphology grading alone, subgroup >35 years age. Aneuploidy screening shortens time birth However, is not without risk (false positive false negative “no read” results embryonic damage), significant financial cost, should only be used conjunction counseling under supervision qualified infertility subspecialist. most cost-effective among ≥38 PGT-M PGT-SR offer useful low-risk debilitating inherited disorders. Significant advances been made ability analyze human embryos abnormalities. Screening monogenic potentially eliminates disease transmission subsequent generations. Optimization these molecular techniques remains necessary decrease rates. Additional study mosaicism needed clarify which are appropriate transfer.

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ژورنال

عنوان ژورنال: F&S reviews

سال: 2021

ISSN: ['2666-5719']

DOI: https://doi.org/10.1016/j.xfnr.2020.10.001